PROSITE: PDOC00787 (documentation file)

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# PROSITE: PDOC00787 (documentation)

    {PDOC00787}
    {PS01027; GLYCOSYL_HYDROL_F39}
    {BEGIN}
    ******************************************************
    * Glycosyl hydrolases family 39 putative active site *
    ******************************************************

    It has  been  shown  [1,E1]  that  the  following  glycosyl  hydrolases can be
    classified into a single family on the basis of sequence similarities:

     - Mammalian lysosomal alpha-L-iduronidase (EC 3.2.1.76).
     - Caldocellum  saccharolyticum  and  Thermoanaerobacter saccharolyticum beta-
       xylosidase (EC 3.2.1.37) (gene xynB).

    The best  conserved  regions  in  these  enzymes is  located in the N-terminal
    section. It   contains  a  glutamic  acid  residue  which,  on  the  basis  of
    similarities with other  families of glycosyl hydrolases [2], probably acts as
    the proton donor in the catalytic mechanism. We use this region as a signature
    pattern.

    -Consensus pattern: W-x-F-E-x-W-N-E-P-[DN]
                        [The second E is the putative active site residue]
    -Sequences known to belong to this class detected by the pattern: ALL.
    -Other sequence(s) detected in SWISS-PROT: NONE.

    -Expert(s) to contact by email:
                       Henrissat B.; bernie@afmb.cnrs-mrs.fr

    -Last update: November 1997 / Text revised.

    [ 1] Henrissat B., Bairoch A.
         Biochem. J. 293:781-788(1993).
    [ 2] Henrissat B., Callebaut I., Fabrega S., Lehn P., Mornon J.-P., Davies G.
         Proc. Natl. Acad. Sci. U.S.A. 92:7090-7094(1995).
    [E1] http://www.expasy.ch/cgi-bin/lists?glycosid.txt

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    {END}

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