ENTRY       EC 1.1.1.1
NAME        Alcohol dehydrogenase
            Aldehyde reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Alcohol:NAD+ oxidoreductase
REACTION    Alcohol + NAD+ = Aldehyde or Ketone + NADH
SUBSTRATE   NAD+
            Primary alcohol
            Secondary alcohol
            Cyclic secondary alcohol
            Hemiacetal
PRODUCT     Aldehyde
            Ketone
            NADH
COFACTOR    Zinc
COMMENT     A zinc protein. Acts on primary or secondary alcohols or
            hemiacetals; the animal, but not the yeast, enzyme acts also on
            cyclic secondary alcohols
            The insect enzyme is a member of the nonmetallo-short-chain
            alcohol dehydrogenase (ADH) family (Proc.Natl.Acad.Sci.USA(1991)
            88, 10064-10068).
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00120  Bile acid biosynthesis
            PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b0356(adhC) b1241(adhE) b1478(adhP) b3589(yiaY)
            ECE: Z0456(adhC) Z2016(adhE) Z2232(adhP) Z5010(yiaY)
            ECS: ECs0411 ECs1741 ECs2082 ECs4466
            HIN: HI0185(adhC)
            XFA: XF1746 XF2389
            VCH: VC1147 VC2033
            PAE: PA2119 PA2158 PA2188 PA3629(adhC) PA5427(adhA)
            PMU: PM1453(adh2)
            NME: NMB0546 NMB1304
            NMA: NMA0725(adhA) NMA1518(adhC)
            MLO: mlr0872 mlr1136 mlr1178
            CCR: CC2516 CC3029
            BSU: BS2776(adhB) BS3211(gbsB)
            BHA: BH1829(adhB)
            LLA: L13145(adhE) L55758(adhA)
            SPY: SPy0044(adhA)
            MTU: Rv0761c(adhB) Rv1862(adhA) Rv2259(adhE2)
            MLE: ML1784(adhE2) ML2053
            SYN: sll0990
            AAE: aq_1240(adh2) aq_1362(adh1)
            TMA: TM0111 TM0920
            AFU: AF0024 AF0339 AF2019 AF2101
            HAL: VNG1821G(adh4)
            TAC: Ta0832 Ta0833 Ta0841
            TVO: TVG0387048 TVG0995648 TVG1348694
            PHO: PH0743
            PAB: PAB1511
            APE: APE1245 APE1557 APE1963 APE2239
            SSO: SSO0472(adh-1) SSO0764(adh-2) SSO1220(adh-3) SSO1300(adh-4)
                 SSO1646(adh-5) SSO2334(adh-6) SSO2441(adh-7) SSO2494(adh-8)
                 SSO2501(adh-9) SSO2536(adh-10) SSO2717(adh-11) SSO2800(adh-12)
                 SSO2878(adh-13)
            SCE: YBR145W(ADH5) YDL168W(SFA1) YGL256W(ADH4) YMR083W(ADH3)
                 YMR303C(ADH2) YOL086C(ADH1)
            SPO: ADH1(adh1) SPAC5H10.06C(spac5h10.06c) SPCC13B11.04C
            ATH: At1g77120(F22K20_19)
            CEL: K12G11.3 K12G11.4
            DME: CG3425(T3dh) CG3481(Adh) CG6598(Fdh)
            MMU: 1098256(Daq1) 87921(Adh1) 87926(Adh3) 87929(Adh5)
            HSA: 124(ADH1) 125(ADH2) 126(ADH3) 127(ADH4) 128(ADH5) 130(ADH6)
                 131(ADH7)
DISEASE     MIM: 103700  Alcohol dehydrogenase (class I), alpha polypeptide
            MIM: 103720  Alcohol dehydrogenase (class I), beta polypeptide
            MIM: 103730  Alcohol dehydrogenase (class I), gamma polypeptide
            MIM: 103740  Alcohol dehydrogenase (class II), pi polypeptide
            MIM: 600086  Alcohol dehydrogenase-7
MOTIF       PS: PS00059  G-H-E-x(2)-G-x(5)-[GA]-x(2)-[IVSAC]
            PS: PS00060  [GSW]-x-[LIVTSACD]-[GH]-x(2)-[GSAE]-[GSHYQ]-x-[LIVTP]-
                         [GAST]-[GAS]-x(3)-[LIVMT]-x-[HNS]-[GA]-x-[GTAC]
            PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
            PS: PS00913  [STALIV]-[LIVF]-x-[DE]-x(6,7)-P-x(4)-[ALIV]-x-[GST]-
                         x(2)-D-[TAIVM]-[LIVMF]-x(4)-E
STRUCTURES  PDB: 1A4U  1A71  1A72  1ADB  1ADC  1ADF  1ADG  1AGN  1AXE  1AXG  
                 1B14  1B15  1B16  1B2L  1BTO  1CDO  1D1S  1D1T  1DDA  1DEH  
                 1E3E  1E3I  1E3L  1EE2  1HDX  1HDY  1HDZ  1HET  1HEU  1HF3  
                 1HLD  1HSO  1HSZ  1HT0  1HTB  1LDE  1LDY  1QLH  1QLJ  1TEH  
                 2OHX  2OXI  3BTO  3HUD  5ADH  6ADH  7ADH  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.1
            ExPASy - ENZYME nomenclature database: 1.1.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.1
            BRENDA, the Enzyme Database: 1.1.1.1
            SCOP (Structural Classification of Proteins): 1.1.1.1
///
ENTRY       EC 1.1.1.62
NAME        Estradiol 17beta-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Estradiol-17beta:NAD(P)+ 17-oxidoreductase
REACTION    Estradiol-17beta + NAD+ or NADP+ = Estrone + NADH or NADPH
SUBSTRATE   Estradiol-17beta
            (S)-20-Hydroxypregn-4-en-3-one
            NAD+
            NADP+
PRODUCT     Estrone
            (S)-Pregn-4-en-3,20-dione
            NADH
            NADPH
COMMENT     Also acts on (S)-20-hydroxypregn-4-en-3-one and related
            compounds, oxidizing the (S)-20-group. B-specific with respect
            to NAD(P)+ (cf. EC 1.1.1.149).
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
GENES       CEL: F11A5.12
            DME: CG1444 CG3415
            HSA: 3292(HSD17B1) 3293(HSD17B3) 3294(HSD17B2) 3295(HSD17B4)
                 3296(HSD17BP1) 51478(HSD17B7)
DISEASE     MIM: 109685  Hydroxysteroid (17-beta) dehydrogenase 2
            MIM: 264300  Hydroxysteroid (17-beta) dehydrogenase 3
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
            PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
STRUCTURES  PDB: 1FDT  1FDS  1FDV  1FDW  1IOL  3DHE  1EQU  1DHT  1BHS  1A27  
                 1FDU  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.62
            ExPASy - ENZYME nomenclature database: 1.1.1.62
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.62
            BRENDA, the Enzyme Database: 1.1.1.62
            SCOP (Structural Classification of Proteins): 1.1.1.62
///
ENTRY       EC 1.1.1.68
NAME        Transferred to EC 1.7.99.5
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Transferred entry. Now EC 1.7.99.5 -
            5,10-Methylenetetrahydrofolate reductase (FADH2).
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.68
            ExPASy - ENZYME nomenclature database: 1.1.1.68
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.68
///
ENTRY       EC 1.6.5.3
NAME        NADH dehydrogenase (ubiquinone)
            Ubiquinone reductase
            Type I dehydrogenase
            Complex I dehydrogenase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With quinone or related compound as acceptor
SYSNAME     NADH:ubiquinone oxidoreductase
REACTION    NADH + Ubiquinone = NAD+ + Ubiquinol
SUBSTRATE   NADH
            Ubiquinone
PRODUCT     NAD+
            Ubiquinol
COFACTOR    FAD
            Iron
            Sulfur
COMMENT     A flavoprotein (FAD) containing iron-sulfur contres. The complex,
            present in mitochondria, can be degraded to form EC 1.6.99.3.
PATHWAY     PATH: MAP00130  Ubiquinone biosynthesis
            PATH: MAP00190  Oxidative phosphorylation
GENES       ECO: b2276(nuoN) b2277(nuoM) b2278(nuoL) b2279(nuoK) b2280(nuoJ)
                 b2281(nuoI) b2282(nuoH) b2283(nuoG) b2284(nuoF) b2285(nuoE)
                 b2286 b2287(nuoB) b2288(nuoA)
            ECE: Z3534(nuoN) Z3536(nuoM) Z3537(nuoL) Z3538(nuoK) Z3539(nuoJ)
                 Z3540(nuoI) Z3541(nuoH) Z3542(nuoG) Z3543(nuoF) Z3544(nuoE)
                 Z3545(nuoC) Z3546(nuoB) Z3547(nuoA)
            ECS: ECs3160 ECs3161 ECs3162 ECs3163 ECs3164 ECs3165 ECs3166
                 ECs3167 ECs3168 ECs3169 ECs3170 ECs3171 ECs3172
            XFA: XF0305 XF0306 XF0307 XF0308 XF0309 XF0310 XF0311 XF0312
                 XF0313 XF0314 XF0315 XF0316 XF0317 XF0318
            VCH: VC1581 VCA0155 VCA0157
            PAE: PA1054 PA1056 PA1883 PA2637(nuoA) PA2638(nuoB) PA2639(nuoD)
                 PA2640(nuoE) PA2641(nuoF) PA2642(nuoG) PA2643(nuoH)
                 PA2644(nuoI) PA2645(nuoJ) PA2646(nuoK) PA2647(nuoL)
                 PA2648(nuoM) PA2649(nuoN)
            BUC: BU154(nuoA) BU155(nuoB) BU156(nuoCD) BU157(nuoE) BU158(nuoF)
                 BU159(nuoG) BU160(nuoH) BU161(nuoI) BU162(nuoJ) BU163(nuoK)
                 BU164(nuoL) BU165(nuoM) BU166(nuoN)
            NME: NMB0241 NMB0242 NMB0243 NMB0244 NMB0245 NMB0246 NMB0249
                 NMB0250 NMB0251 NMB0253 NMB0254 NMB0257 NMB0258 NMB0259
            NMA: NMA0002(nuoL) NMA0005(nuoK) NMA0006(nuoJ) NMA0008(nuoI)
                 NMA0009(nuoH) NMA0010(nuoG) NMA0014(nuoF) NMA0015(nuoE)
                 NMA0016(nuoD) NMA0017(nuoC) NMA0018(nuoB) NMA0019(nuoA)
                 NMA0747(nqrF) NMA2228(nuoN) NMA2229(nuoM)
            HPY: HP1260(NQO7) HP1261(NQO6) HP1262(NQO5) HP1263 HP1264 HP1265
                 HP1266(NQO3) HP1267(NQO8) HP1268(NQO9) HP1269(NQO10) HP1270
                 HP1271(NQO12) HP1272(NQO13) HP1273(NQO14)
            HPJ: jhp1181 jhp1182 jhp1183 jhp1184 jhp1185 jhp1186 jhp1187
                 jhp1188 jhp1189 jhp1190 jhp1191 jhp1192 jhp1193 jhp1194
            CJE: Cj1566c(nuoN) Cj1567c(nuoM) Cj1568c(nuoL) Cj1569c(nuoK)
                 Cj1570c(nuoJ) Cj1571c(nuoI) Cj1572c(nuoH) Cj1573c(nuoG)
                 Cj1574c Cj1575c Cj1576c(nuoD) Cj1577c(nuoC) Cj1578c(nuoB)
                 Cj1579c(nuoA)
            RPR: RP115(nuoF) RP282(nuoL3) RP283(nuoL2) RP284(nuoN2)
                 RP353(nuoE) RP354(nuoD) RP355(nuoC) RP356(nuoB) RP357(nuoA)
                 RP537(nuoN1) RP790(nuoJ) RP791(nuoK) RP792(nuoL1) RP793(nuoM)
                 RP795(nuoI) RP796(nuoH) RP797(nuoG)
            MLO: mll1352 mll1354 mll1355 mll1357 mll1358 mll1359 mll1361
                 mll1362 mll1364 mll1365 mll1366 mll1367 mll1369 mll1371
                 mll1372 mll5193 mll5397 mll5398
            CCR: CC1937 CC1938 CC1939 CC1940 CC1941 CC1942 CC1945 CC1946
                 CC1947 CC1950 CC1952 CC1954 CC1955 CC1956
            BSU: BS0231(ndhF)
            MTU: Rv3145(nuoA) Rv3146(nuoB) Rv3147(nuoC) Rv3148(nuoD)
                 Rv3149(nuoE) Rv3150(nuoF) Rv3151(nuoG) Rv3152(nuoH)
                 Rv3153(nuoI) Rv3154(nuoJ) Rv3155(nuoK) Rv3156(nuoL)
                 Rv3157(nuoM) Rv3158(nuoN)
            SYN: sll0026(ndhF) sll0027(ndhD4) sll0223(ndhB) sll0519(ndhA)
                 sll0520(ndhI) sll0521(ndhG) sll0522(ndhE) sll1220
                 sll1221(hoxF) sll1223(hoxU) sll1732(ndhF) sll1733(ndhD3)
                 slr0261(ndhH) slr0331(ndhD1) slr0844(ndhF) slr1279(ndhC)
                 slr1280(psbg1) slr1281(ndhJ) slr1291(ndhD2) slr2007(ndhD5)
                 slr2009(ndhD6)
            DRA: DR0880 DR1492 DR1493 DR1494 DR1495 DR1496 DR1497 DR1498
                 DR1499 DR1500 DR1501 DR1503 DR1504 DR1505 DR1506
            AAE: aq_1310(nuoA2) aq_1312(nuoB) aq_1314(nuoD2) aq_1315(nuoH1)
                 aq_1317(nuoI1) aq_1318(nuoJ1) aq_1319(nuoK1) aq_1320(nuoL1)
                 aq_1321(nuoM1) aq_1322(nuoN1) aq_135(nueM) aq_1373(nuoH2)
                 aq_1374(nuoH3) aq_1375(nuoI2) aq_1377(nuoJ2) aq_1378(nuoK2)
                 aq_1379(nuoL3) aq_1382(nuoM2) aq_1383(nuoN2) aq_1385(nuoA1)
                 aq_437(nuoG) aq_551(nuoD1) aq_573(nuoF) aq_574(nuoE)
                 aq_866(nuoL2)
            TMA: TM0010 TM0011 TM0012 TM0201 TM0228 TM1105 TM1211 TM1212
                 TM1213 TM1214 TM1215 TM1216 TM1424 TM1425 TM1426
            MJA: MJ0520 MJ1309(cooM) MJ1362
            MTH: MTH1237 MTH1246 MTH1548 MTH1549 MTH393
            AFU: AF1823 AF1824 AF1825(nuoM) AF1826(nuoL) AF1827 AF1828 AF1829
                 AF1830(nuoD) AF1831
            HAL: VNG0635G(nolB) VNG0636G(ndhG1) VNG0637G(ndhG5)
                 VNG0639G(ndhG4) VNG0640G(nolD) VNG0641C VNG0643G(nolC)
                 VNG0646G(nuoL) VNG0647G(nuoM) VNG0648G(ndhG3)
            TAC: Ta0959 Ta0960 Ta0961 Ta0962 Ta0964 Ta0965 Ta0966 Ta0967
                 Ta0968 Ta0969 Ta0970
            TVO: TVG1157047 TVG1158465 TVG1160017 TVG1161017 TVG1162018
                 TVG1162541 TVG1162786 TVG1163214 TVG1164251 TVG1165354
                 TVG1165809 TVG1166270
            PHO: PH0941 PH0942 PH1431 PH1446 PH1447 PH1448 PH1449 PH1450
                 PH1451 PH1452 PH1453
            PAB: PAB0488 PAB0490(nuoM) PAB0492(nuoH) PAB0493(nuoB)
                 PAB0494(nuoC) PAB0495(nuoD) PAB0496(nuoI) PAB0805 PAB0806
                 PAB1888 PAB2416(nuoN)
            APE: APE1410 APE1411 APE1415 APE1417 APE1418 APE1419 APE1421
                 APE1422 APE1426 APE1428 APE1430
            SSO: SSO0322(NuoA) SSO0323(NuoC) SSO0324(NuoD) SSO0325(NuoH)
                 SSO0326(NuoI) SSO0327(NuoJ) SSO0328(NuoL) SSO0329(NuoN)
                 SSO0665(NuoB)
            SCE: YKL192C(ACP1)
            SPO: SPAC11E3.12(spac11e3.12) SPAC4H3.09(spac4h3.09)
                 SPBC18E5.10(spbc18e5.10)
            ATH: AT4g02580(T10P11_14) AT5g08530(MAH20_9) AT5g11770(T22P22_160)
                 AT5g37510(mpa22_p_40) At1g16700(F19K19_1) At1g65290(T8F5_6)
                 At1g79010(YUP8H12R_21) At1g79200(YUP8H12R_37)
                 At2g02050(F14H20.12) At2g20360(F11A3.9) At2g44620(F16B22.11)
            CEL: C09H10.3 C16A3.4 C18E9.4 C25A1.13 C33A12.1 D2030.4 F16B4.6
                 F22D6.4 F37C12.3 F44G4.2 F53F4.10 F59C6.5 K04G7.4
                 K09A9.5(gas-1) T10E9.7 T20H4.5 T26A5.3 W10D5.2 Y51H1A.3a
                 Y51H1A.3b Y57G11C.12 Y63D3A.7
            DME: CG10320 CG11423 CG11913 CG12079 CG15328 CG15434 CG1970 CG2014
                 CG2286(ND75) CG3192 CG3621(EG:152A3.7) CG3683 CG3944 CG5548
                 CG5703 CG6020 CG6343(ND42) CG6463 CG6485 CG6914 CG7712 CG8102
                 CG8844 CG9140 CG9160(mtacp1) CG9160_1(mtacp1) CG9172 CG9306
                 CG9762
            HSA: 4535(MTND1) 4536(MTND2) 4537(MTND3) 4538(MTND4) 4539(MTND4L)
                 4540(MTND5) 4541(MTND6) 4694(NDUFA1) 4695(NDUFA2) 4696(NDUFA3)
                 4697(NDUFA4) 4698(NDUFA5) 4700(NDUFA6) 4701(NDUFA7)
                 4702(NDUFA8) 4704(NDUFA9) 4705(NDUFA10) 4706(NDUFAB1)
                 4707(NDUFB1) 4708(NDUFB2) 4709(NDUFB3) 4710(NDUFB4)
                 4711(NDUFB5) 4712(NDUFB6) 4713(NDUFB7) 4714(NDUFB8)
                 4715(NDUFB9) 4716(NDUFB10) 4717(NDUFC1) 4718(NDUFC2)
                 4719(NDUFS1) 4720(NDUFS2) 4722(NDUFS3) 4723(NDUFV1)
                 4724(NDUFS4) 4725(NDUFS5) 4726(NDUFS6) 4727(NDUFS7)
                 4728(NDUFS8) 4729(NDUFV2) 4731(NDUFV3)
DISEASE     MIM: 300078  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1,
                         7.5kD
            MIM: 601677  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
                         (13kD, B13)
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
            PS: PS00535  [LIVMH]-H-[RT]-[GA]-x-E-K-[LIVMTN]-x-E-x-[KRQ]
            PS: PS00542  E-R-E-x(2)-[DE]-[LIVMFY](2)-x(6)-[HK]-x(3)-[KRP]-x-
                         [LIVM]-[LIVMYS]
            PS: PS00641  P-x(2)-C-[YWSD]-x(7)-G-x-C-R-x-C
            PS: PS00642  C-P-x-C-[DE]-x-[GS](2)-x-C-x-L-Q
            PS: PS00643  R-C-[LIVM]-x-C-x-R-C-[LIVMT]-x-[LMFY]
            PS: PS00644  G-[AM]-G-[AR]-Y-[LIVM]-C-G-[DE](2)-[STA](2)-[LIM](2)-
                         [END]-S
            PS: PS00645  E-[ST]-C-G-x-C-x-P-C-R-x-G
            PS: PS00667  G-[LIVMFYKRS]-[LIVMAGP]-Q-x-[LIVMFY]-x-D-[AGIM]-
                         [LIVMFTA]-K-[LVMYST]-[LIVMFYG]-x-[KR]-[EQG]
            PS: PS00668  P-F-D-[LIVMFYQ]-[STAGPVM]-E-[GAC]-E-x-[EQ]-[LIVMS]-
                         x(2)-G
            PS: PS01099  D-x(2)-F-[STK]-x(5)-C-[LM]-G-x-C-x(2)-[GA]-P
            PS: PS01150  [GN]-x-D-[KRHST]-[LIVMF](2)-P-[IV]-D-[LIVMFYW](2)-x-P-
                         x-C-P-[PT]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.5.3
            ExPASy - ENZYME nomenclature database: 1.6.5.3
            WIT (What Is There) Metabolic Reconstruction: 1.6.5.3
            BRENDA, the Enzyme Database: 1.6.5.3
///
ENTRY       EC 1.14.13.28
NAME        3,9-Dihydroxypterocarpan 6a-monooxygenase
            3,9-Dihydroxypterocarpan 6a-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     (6aR,11aR)-3,9-Dihydroxypterocarpan,NADPH:oxygen oxidoreductase
            $ (6a-hydroxylating)
REACTION    (6aR,11aR)-3,9-Dihydroxypterocarpan + NADPH + O2 =
            (6aS,11aS)-3,6a,9-Trihydroxypterocarpan + NADP+ + H2O
SUBSTRATE   (6aR,11aR)-3,9-Dihydroxypterocarpan
            NADPH
            O2
PRODUCT     (6aS,11aS)-3,6a,9-Trihydroxypterocarpan
            NADP+
            H2O
COFACTOR    Heme
COMMENT     Possibly a heme-thiolate protein (P-450).  The product of the
            reaction is the biosynthetic precursor of the phytoalexin
            glyceollin in soybean.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.28
            ExPASy - ENZYME nomenclature database: 1.14.13.28
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.28
            BRENDA, the Enzyme Database: 1.14.13.28
///
ENTRY       EC 2.4.1.68
NAME        Glycoprotein 6-alpha-L-fucosyltransferase
            GDPfucose--glycoprotein fucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked
            $ N-acetylglucosamine of N-acetyl-beta-D-glucosaminyl-1,2-alpha-
            $D-mannosyl-1,3-(R1-alpha-1,6)-beta-D-mannosyl-1,4-beta-N-acetyl-
            $D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl)asparagine 6-alpha-L-
            $fucosyltransferase
REACTION    GDP-L-fucose + N4-(N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-
            $mannosyl-1,3-(R1-alpha-1,6)-beta-D-mannosyl-beta-N-acetyl-1,4-
            $D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl)asparagine = GDP +
            N4-(N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-
            $(R1-alpha-1,6)-beta-D-mannosyl-1,4-beta-N-acetyl-D-glucosaminyl-
            $1,4-(alpha-L-fucosyl-1,6)-N-acetyl-D-glucosaminyl)asparagine
SUBSTRATE   GDP-L-fucose
            N4-(N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-
            $(R1-alpha-1,6)-beta-D-mannosyl-beta-N-acetyl-1,4-D-glucosaminyl-
            $1,4-N-acetyl-D-glucosaminyl)asparagine
PRODUCT     GDP
            N4-(N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-
            $(R1-alpha-1,6)-beta-D-mannosyl-1,4-beta-N-acetyl-D-glucosaminyl-
            $1,4-(alpha-L-fucosyl-1,6)-N-acetyl-D-glucosaminyl)asparagine
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.68
            ExPASy - ENZYME nomenclature database: 2.4.1.68
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.68
            BRENDA, the Enzyme Database: 2.4.1.68
///
ENTRY       EC 3.1.1.6
NAME        Acetylesterase
            C-esterase (in animal tissues)
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Acetic-ester acetylhydrolase
REACTION    an Acetic ester + H2O = an Alcohol + Acetate
SUBSTRATE   Acetic ester
            H2O
PRODUCT     Alcohol
            Acetate
GENES       MMU: 95428(Es17)
STRUCTURES  PDB: 1BS9  1G66  2AXE  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.6
            ExPASy - ENZYME nomenclature database: 3.1.1.6
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.6
            UM-BBD (Biocatalysis/Biodegradation Database): 3.1.1.6
            BRENDA, the Enzyme Database: 3.1.1.6
            SCOP (Structural Classification of Proteins): 3.1.1.6
///
ENTRY       EC 2.7.2.1
NAME        Acetate kinase
            Acetokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
SYSNAME     ATP:acetate phosphotransferase
REACTION    ATP + Acetate = ADP + Acetyl phosphate
SUBSTRATE   ATP
            Acetate
            Propanoate
PRODUCT     ADP
            Acetyl phosphate
            Propanoyl phosphate
COMMENT     Propanoate also acts as acceptor, but more slowly.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00640  Propanoate metabolism
MOTIF       PS: PS01075  [LIVM](2)-x-[LIVM]-N-x-G-S-[ST]-S-x-K
            PS: PS01076  [LIVMA](2)-x(2)-H-x-G-x-G-x-S-[LIVM]-x-[AV]-x(3)-G
GENES       ECO: ECOLI_2245(ackA)
            HIN: HI1204(ackA)
            BSU: ackA
            MGE: MG357(ackA)
            MPN: G12_orf390(ackA)
            SYN: sll1299(ackA)
DBLINKS     University of Geneva ENZYME DATA BANK: 2.7.2.1
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.1
            PIR: B49338  B49935  E64239  KIECAA  
///
